Program of Experimental Medicine - POEM
Department of Medicine

Program of Experimental Medicine
POEM


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Cardiology
PAVEL ANTIPEROVITCH, MD, FRCPC, Assistant Professor



General Internal Medicine
ANDREW APPLETON, MD, FRCPC, Associate Professor

Andrew Appleton is an Associate Professor in Division of General Internal Medicine. He practices acute inpatient medicine, ambulatory general medicine, cardiometabolic health and lifestyle medicine at University Hospital. He completed medical school and residency training at Western University. He completed a Master's of Health Sciences in Health Administration at the University of Toronto. He completed health services research training with ICES at Western. He is board certified with the American Board of Lifestyle Medicine. His main clinical interest is in the management of cardiometabolic health optimization with an emphasis on lifestyle. His academic focus is on quality improvement of integrated care delivery models.

Keywords:
Cardiometabolic Health
Chronic disease
Delivery models
Disease Reversal
Integrated care
Integrated database
Lifestyle Medicine
Prevention
Quality improvement


Rheumatology
TOM APPLETON, MD, PhD, FRCPC, Assistant Professor

Dr. Appleton is a Rheumatologist and Scientist at the Lawson Health Research Institute at the Rheumatology Centre at St. Joseph’s Health Care, London. He was recruited back to Western as Clinician-Scientist and Assistant Professor of Medicine in October, 2016. He has focused expertise in basic/translational medical research, musculoskeletal ultrasound, and clinical research, including clinical trials. His research focus is in osteoarthritis (OA), the most common joint disease world-wide. Dr. Appleton is the director of the Western Rheumatology Multidisciplinary Specialty Centre for Osteoarthritis and the principal investigator of the Western Ontario Registry for Early Osteoarthritis (WOREO) Knee Cohort study. His work in translational biology using transcriptomics and advanced molecular biology techniques in animal models of post-traumatic knee osteoarthritis led to the discovery of transforming growth factor alpha as a cartilage-derived determinant of early joint damage. This discovery has since been confirmed by others in multi-continent genome-wide association studies for both hip and knee osteoarthritis.

Dr. Appleton is recognized internationally as an emerging expert in OA, including the pathogenesis of early OA and OA phenotyping. He has been an invited speaker at the largest clinical international Rheumatology and OA research-focused conferences, including the American College of Rheumatology (ACR) and the Osteoarthritis Research Society international (OARSI). His translational biology work has resulted in more than 60 peer-reviewed publications in top arthritis and Rheumatology journals and presentations at national and international conferences. Dr. Appleton currently holds independent operating grants as nominated principal investigator from the Ontario Innovation Fund, the Arthritis Society of Canada, and the Western Bone and Joint Institute, and is the site principal investigator on a national multicenter randomized controlled trial of disease modifying treatment for knee osteoarthritis. He currently supervises a research team of 9 post-doctoral, graduate, and undergraduate trainees and research associates.

Dr. Appleton is also an investigator with provincial and national research initiatives including the Canadian early ArthriTis CoHort Study (CATCH), a prospective study of patients with early rheumatoid arthritis. He has been recognized as a Future Leader in Rheumatology by the Canadian Rheumatology Association and the United States Bone and Joint Initiative. He is currently Chair of the Annual Scientific Meeting Planning Committee for the Canadian Rheumatology Association and a member of the board of directors of the Ontario Rheumatology Association.

Keywords:
Cartilage
Cell signalling
Clinical Trials
Early osteoarthritis
Inflammation
Osteoarthritis
Rheumatology
Synovitis
Ultrasound


Gastroenterology
JUAN PABLO ARAB, MD, FRCPC, Associate Professor

Dr. Arab is Associate Professor of Medicine at the Division of Gastroenterology, Department of Medicine, and the Department of Epidemiology and Biostatistics at Schulich School of Medicine, Western University, London, Ontario, Canada. Trained at the Pontificia Universidad Catolica, Chile and Mayo Clinic, Rochester, MN, USA. Dr. Arab is a Gastroenterology and Hepatology specialist, Transplant Hepatologist and Clinical Researcher with interest in clinical/translational research and epidemiology in alcohol-related liver disease and non-alcoholic fatty liver disease. He has published more than 150 peer-reviewed papers, co-authored several book chapters and delivered lectures on liver-related topics at national and international meetings. He is an Associate Editor for Hepatology (flagship AASLD journal). He has also participated in the generation of clinical practice guidelines for alcohol-related liver disease, nonalcoholic fatty liver disease, and hepatorenal syndrome and regularly serves as expert reviewer of research grants and scientific research abstracts for multiple societies, funding agencies and international peer reviewed journals. Additionally, he is spearheading international collaboration groups aiming to study alcohol-associated liver disease and non-alcoholic fatty liver disease (AH-LATIN and Global AlcHep BigData Network). Dr. Arab is member of the AASLD Global Outreach and Engagement Committee. He is currently the Vice-Chair of the Special Interest Group on alcohol-associated liver disease of the AASLD. Additionally, he is the Vice-Chair of the Education & Scholarship Committee of the International Liver Transplantation Society (ILTS).

Keywords:
Alcohol-associated liver disease
Cirrhosis
Fatty liver
Liver cancer
Liver transplantation
NAFLD


Gastroenterology
SAMUEL ASFAHA, MD, PhD, FRCPC, Assistant Professor

Dr. Asfaha received his PhD and medical degrees from University of Calgary Canada in 2000 and 2003, respectively. After completing his internal medicine residency training at the University of Alberta, he returned to the University of Calgary to complete his Gastroenterology fellowship. He then pursued a postdoctoral research fellowship in stem cells and cancer at Columbia University in the City of New York, where he was eventually promoted to a junior faculty position as an Instructor in Medicine. He was then recruited to the University of Western Ontario as an Assistant Professor and Schulich Clinician Scientist. He currently leads a team of researchers focused on intestinal stem cells and cellular origin of colorectal cancer.

Keywords:
Colorectal cancer
Inflammation
Inflammatory bowel diseases
Stem Cells