Program of Experimental Medicine - POEM
Department of Medicine

Program of Experimental Medicine
POEM


 Cardiology,  Cl Immunology and Allergy,  Clinical Pharmacology,  Critical Care Medicine, 
 Endocrinology and Metabolism, 
 Gastroenterology,  General Internal Medicine,  Geriatric Medicine, 
 Hematology, 
 Infectious Diseases, 
 Nephrology, 
 Respirology,  Rheumatology, 


Nephrology
Peter.Blake@lhsc.on.ca
PETER BLAKE, MD, FRCPC, FRCPI, MB, MSc (Hons), Professor

Dr. Peter Blake is a Professor of Medicine in the Division of Nephrology at the University of Western Ontario and London Health Sciences Centre in London, Ontario. Over the past two decades, Dr. Blake has published over 100 papers in the area of peritoneal dialysis and adequacy of dialysis in general.

He has been Editor of two major textbooks in Nephrology. He has served as Editor-in-Chief since 2001 of Peritoneal Dialysis International. He is or has been a member of the Editorial Boards of the Journal of the American Society of Nephrology, the American Journal of Nephrology, Advances in Renal Replacement Therapy, and Nephrology News and Issues. He has given over 200 invited talks in 25 different countries.

Dr. Blake has served on the National Kidney Foundation K/DOQI Peritoneal Dialysis Work Group, and the International Society of Peritoneal Dialysis Council (ISPD). He has been Chair of the Canadian Society of Nephrology Work Group on Peritoneal Dialysis since 1998 and has Co-Chaired the International Society of Nephrology (ISN) North American Task Force on Renal Disasters on behalf of the ISN Acute Renal Failure Commission. In 2013, he was appointed Provincial Medical Director of the Ontario Renal Network (ORN), the agency that administers renal services in Ontario.

Dr. Blake graduated from University College Dublin Medical School in 1980. He received his Masters degree in Immunology from the University of Alberta in 1992. He also holds the FRCPC, Royal College of Physicians of Canada and the FRCPI, Royal College of Physicians of Ireland.

Keywords:
Dialysis delivery systems internationally
Dialysis dose: Optimization of with particular regard to peritoneal dialysis
Dialysis patients: Malnutrition
Dialysis patients: Registry studies
Dialysis: Economics
Dialysis: Prescription and adequacy (Major Focus)
Hemodialysis: Recirculation and urea rebound
Peritoneal dialysis prescriptions: Patient compliance
Peritoneal dialysis: Determinants of outcome in patients


Nephrology
Michael.Chiu@lhsc.on.ca
MICHAEL CHIU, MD, FRCPC, Assistant Professor

Dr. Michael Chiu is a Nephrologist and an Assistant Professor with the Department of Medicine, Division of Nephrology, at the University of Western Ontario. He completed his nephrology training in 2019 at the University of Western Ontario along with subspecialty training in home dialysis in 2020. Over this time, Dr. Chiu also completed a Masters of Science in Healthcare Quality through Queens University in 2020.

Dr. Chiu’s research interests are in Chronic Kidney Disease, Home Dialysis, and Quality Improvement.

Keywords:
Chronic Kidney Disease
Home Dialysis
Quality Improvement


Nephrology
Dervla.Connaughton@lhsc.on.ca
Dr. Dervla Connaughton, MD, PhD, Assistant Professor of Medicine

Dr. Dervla Connaughton is an Assistant Professor of Medicine in the Division of Nephrology at Western University and currently is the inaugural Eugen Drewlo Chair for Kidney Research and Innovation at the Schulich School of Medicine & Dentistry.

She received her medical degree and specialist training from the Royal College of Surgeons in Ireland and completed a transplant fellowship at the National Centre for Nephrology and Transplantation at Beaumont Hospital in Ireland.

She was awarded her PhD degree from Trinity College Dublin in renal genetics and a Master’s of Science in Epidemiology from the London School of Hygiene and Tropical Medicine.

She also completed a fellow fellowship at Harvard University and Boston Children's Hospital where she carried out genetic research investigating monogenic causes of chronic kidney disease in both adult and pediatric populations. The main focus of research is on understanding the genetic basis and epidemiology of all forms of chronic kidney disease. Specifically, her focus is to establish and characterize the molecular etiology in genetic kidney disease using high throughput sequencing techniques including gene panel sequencing, whole exome and genome sequencing. Dr. Connaughton joined the nephrology division at LHSC in October 2019. She cares for patients with glomerulonephritis, those that require hemodialysis, patients undergoing kidney transplant as well as patient wishing to donate a kidney through the live donation process. She has set up a specialist clinic for the evaluation of patients and their families who may have a genetic form of kidney disease.

Keywords:
Familial nephropathy
Genetics
Glomerulonephritis
Home hemodialysis
Kidney diseases
Monogenic disease
Next generation sequencing
Transplantation
Whole exome sequencing


Nephrology
andrea1.cowan@lhsc.on.ca
ANDREA COWAN, MD, FRCPC, Assistant Professor

Bio sketch and keywords unavailable.


Nephrology
Amit.Garg@lhsc.on.ca
AMIT GARG, MD, FRCPC, FACP, MEd, PhD, Professor

Dr. Amit Garg is Professor of Medicine - Division of Nephrology and of Epidemiology and Biostatistics at Western University. He is the Associate Dean of Clinical Research for the Schulich School of Medicine and Dentistry and is Lead of the ICES Provincial Program focused on Kidney, Dialysis and Transplantation Research (ICES KDT). He is a Scientist at the Lawson Health Research Institute and at ICES, and an Associate Scientist at the Population Health Research Institute.

He is the past medical director of the living kidney donor program at the London Health Sciences Centre, a past president of the Canadian Society of Nephrology, the past Director of the Institute for Clinical Evaluative Sciences (ICES) Western Facility, and the past Medical Lead, Access to Kidney Transplantation for the Ontario Renal Network.

Characterized by his peers as a world-class clinical and health services investigator in kidney, dialysis and transplantation medicine, Dr. Garg feels most fortunate to be able to contribute in this way and is grateful to be supported and surrounded by so many brilliant people, both in the workplace and at home. Working in teams, he has over 600 published articles with more than 1,000 different authors from over 50 international centres (h-index 112).

The research has appeared in top medical journals and in the lay press including CTV, Global News, and the New York Times. It has been widely acknowledged for helping understand how different treatments alter the risk of acute kidney injury from elective surgery, improving the practice and safety of living kidney donation, and reducing adverse events from prescription medications. Additionally, the research has made it easier for fellow researchers and clinicians to systematically search for relevant kidney-related content in large bibliographic databases thanks to the development of specialized filters, and to conduct large-scale randomized trials using streamlined methods.

Dr. Garg has mentored and trained future researchers. He has been the primary research supervisor to over 75 trainees at Western University from who he has learned a great deal. He is also grateful to work with a team of highly qualified research administrators, coordinators, data managers, epidemiologists and statisticians in London, Ontario.

In 2021 Dr. Garg was awarded the Hellmuth Prize, Western University's highest distinction for sustained excellence in research, and the Kidney Foundation of Canada Medal for Research Excellence. In 2016 he received the Donald W. Seldin Young Investigator Award from the American Society of Nephrology, which is presented annually to one individual with an outstanding record of achievement and creativity in basic or patient-orientated research related to the functions and diseases of the kidney.

Keywords:
Clinical trials
Dialysis
Epidemiology
Health Informatics
Health Services Research
Healthcare Databases
Kidney diseases
Medical education
Meta-analysis
Observational studies using administrative databases
Systematic reviews
Transplantation


Nephrology
Lakshman.Gunaratnam@lhsc.on.ca
LAKSHMAN GUNARATNAM, MD, FRCPC, Associate Professor

Dr. Gunaratnam is a nephrologist and Associate Professor of Medicine at Western University. He currently holds the Dr. Robert Zhang Chair in Translational Transplant Research at Western and is Medical Director of Multi-Organ Transplant Program at the London Health Sciences Center. Dr. Gunaratnam completed his undergraduate and graduate studies at the University of Toronto in immunology and then went on to attend medical school and complete residency training in internal medicine at the University of Ottawa. Dr. Gunaratnam completed research fellowships at the University of Ottawa (Dr. Stephen Lee) and Harvard Medical School (Dr. Joseph V. Bonventre) in cancer biology and acute kidney injury, respectively. After completing his clinical fellowship in nephrology at the Massachusetts General Hospital and Brigham and Women’s Hospital in 2009, he did additional training in renal transplantation with Dr. Anil Chandraker at Brigham and Women’s Hospital. He was promoted to Instructor in Medicine at Harvard Medical School and later served as an associate physician at Brigham and Women’s Hospital prior to moving to London, Ontario.

Dr. Gunaratnam leads a basic and translational research program focused on the biological mechanisms underlying acute kidney injury, prolonging the lifespan of kidney transplants, and novel treatments for kidney cancer. His research program is supported by peer-reviewed funding from several agencies including the Canadian Institutes for Health Research, the Kidney Foundation of Canada, the Natural Sciences and Engineering Research Council of Canada, the Government of Ontario, and the Canadian Foundation for Innovation. He holds several advisory and leadership positions in Canadian medical organizations, including, Canadian Blood Services, Trillium Gift of Life Network, Canadian Society of Transplantation, and the Ontario Medical Association.

Keywords:
Acute kidney injury
Cell death
Cell signalling
G proteins
Inflammation
Ischemia-reperfusion injury
Kidney Injury Molecule-1
Phagocytosis
Protein tyrosine phosphorylation


Nephrology
Andrew.House@lhsc.on.ca
ANDREW HOUSE, MD, FRCPC, HBSc, MSc, Professor, Chair, Division of Nephrology

Dr. Andrew House is a Professor in the Faculty of Medicine at the Schulich School of Medicine & Dentistry, Western University, and is currently the Chair of the Western University Division of Nephrology. He did his training in Physiology & Pharmacology at Western before his MD and specialist training at the University of Ottawa, and Masters in Epidemiology & Biostatistics at Western. As a trained clinical epidemiologist and nephrologist, Dr. House focuses on the design and analysis of clinical trials in AKI, CKD, hemodialysis and transplantation. In 2007 he completed a six month sabbatical in Vicenza, Italy, where he developed expertise in Critical Care Nephrology and Cardiorenal Syndromes. He collaborates on research into drug metabolism in varying degrees of chronic kidney disease. He was a member of the ADQI consensus conferences on Cardio-Renal Syndromes held in Venice in 2008 and 2012, and was a Distinguished Faculty at a symposium on Cardio-Renal Syndromes at the American Society of Nephrology Annual Meeting in San Diego, 2009, a symposium on Heart Failure Syndromes at the American Thoracic Society Annual Meeting in New Orleans, 2010, and the Vicenza Course on Hemodialysis in Vicenza, Italy, 2011. He was co-Chair of the international KDIGO Conference on Congestive Heart Failure in May 2017, and invited lecturer on Heart Failure in Chronic Kidney Disease at the 7th Annual Nephrology Summit in Kochin and Hyderabad, India in September 2017. More recently, he helped establish the Adult Tuberous Sclerosis Clinic at LHSC, which he directs, and has turned his research sites on understanding mechanisms and treatments for this complex syndrome.

Keywords:
Cardio-renal syndromes
Cardiovascular disease
Clinical trials
Hemodialysis
Homocysteine
Kidney diseases
Transplantation
Tuberous Sclerosis Complex


Nephrology
susan.huang@lhsc.on.ca
SHIH-HAN SUSAN HUANG, MD, FRCPC, Associate Professor

I have completed my medical degree at the University of Ottawa in 2005 and finished the specialty/subspecialty trainings (internal medicine and nephrology) in 2010 at Western University. In addition, I have successfully completed the Certificate in the Department of Epidemiology and Biostatistics in 2012. In 2015, I received my PhD degree through the Department of Medical Biophysics with the support of numerous research awards, including the Canadian Institute of Health Research (CIHR) Fellowship Award for Health Professional and the Vanier CGS award. My doctoral research was on dialysis adequacy using a new marker, cystatin C. I currently have over 50 publications and over 10 research projects ongoing. My research interests include medical biophysics, TTP and extracoporeal therapies.

Keywords:
Cystatin C
Glomerular nephritis
Hemodialysis
Plasmapheresis


Nephrology
Hariharan.Iyer@lhsc.on.ca
Hariharan Iyer MD, M.Ed., MRCP (UK), FRCP, DRCPSC

Hariharan Iyer is a Nephrologist and an Associate Professor with the Department of Medicine, Division of Nephrology & Transplantation at Western University. After completing his training in General Nephrology and renal transplantation at Western university, he underwent specialized training in high immunological risk renal transplantation and transplant immunology at the Incompatible Kidney Transplant Program, Johns Hopkins University School of Medicine, Baltimore, USA. He is certified in renal transplantation and transplant immunology by the Royal College of Physicians and Surgeons of Canada (RCPSC), American Society of Transplantation (AST) and the European Board of Transplant Medicine. He also holds a master’s degree in Medical education (M.Ed.) from the University of Toronto. He is currently the Program Director of the Nephrology Fellowship training program at Western University and until recently, was the chair of the Undergraduate Medical Education Clinical Methods course. Since joining the Department of Medicine, Dr. Iyer has endeavored and steadfastly worked towards being a dedicated clinician, teacher, and educator, providing leadership to promote and foster learner-centered methodologies, supporting curriculum development and delivery, and assessment of student skills and attitudes at all levels of training so as to enhance and enrich Schulich’s programs. He is an active member of the MD program's curriculum committee and Postgraduate Medical Education (PGME) steering committee and internal review committee.

Recent awards include:
2020 - Schulich School of Medicine and Dentistry Dean's Award of Excellence in Medical Education (Undergraduate),
2017 - Canadian Association of Medical Education (CAME) Certificate of Merit Award
2016 - Department of Medicine Award of Excellence for Innovation in Education
2016 - Schulich School of Medicine and Dentistry Scholar of Merit Award

Keywords:
Competency Based Medical Education
Renal transplantation
Teaching OSCEs


Nephrology
Arsh.Jain@lhsc.on.ca
ARSH JAIN, MD, FRCPC, Associate Professor

Dr. Arsh Jain is an Assistant Professor of Medicine at the University of Western Ontario. He is a practicing Nephrologist at the London Health Sciences Centre and his clinical expertise is in the area of Peritoneal Dialysis. Dr. Jain conducts clinical and health services research to improve health outcomes for patients with kidney diseases.

Keywords:
Chronic kidney disease
Epidemiology
Internal Medicine
Nephrology
Peritoneal dialysis
Time Series Analysis


Nephrology
jevnikar@uwo.ca
ANTHONY JEVNIKAR, MD, FRCPC, Professor

Dr. Jevnikar completed undergraduate and graduate programs in Microbiology and Immunology from The University of Western Ontario and received his MD from the Schulich School of Medicine in 1981. He received further research training in transplant and renal molecular immunology at the Brigham and Women’s Hospital in Boston before returning to Canada in 1991. He is a transplant nephrologist, professor of Medicine, Surgery, and Microbiology & Immunology, Medical Director of Kidney Transplantation and Co-Director of the Multi Organ Transplant Program at University Hospital in London, Ontario. He founded and is currently the Scientific Director of the Matthew Mailing Centre for Translational Transplant Studies at LHRI.

Dr. Jevnikar is a clinician-scientist with a strong focus on translational research as well as patient care. His research has been continuously supported since 1988 by the Kidney Foundation of Canada and the Canadian Institutes of Health Research (CIHR), and the NIH for tolerance work in non-human primates. He has authored or co-authored more than 170 original research publications on both basic and clinical research primarily in transplantation, but also Type I diabetes. In addition to his basic research in epithelial cell injury and the regulation of cellular death by endogenous inhibitors of programmed cell death as a means to promote allograft survival, he also developed other novel research program such as the creation and use of genetically altered plants expressing human proteins to produce biotherapeutics such as cytokines that cannot be practically produced in the quantities required for clinical applications by any other system. He is a strong advocate for the role of clinician-scientists in medical research. He has received awards in recognition of his research contributions, including the Kidney Foundation of Canada Medal for Research Excellence in 2005, the Wyeth-CIHR Chair in Clinical Transplantation in 2008, the Faculty Scholar Award by the Schulich School of Medicine and Dentistry in 2011, and Lifetime Achievement Awards from the Canadian Society of Transplantation (2015) and the Schulich School of Medicine and Dentistry (2016).

Dr. Jevnikar has been an active member of both the Canadian Society of Transplantation (CST) and American Society of Transplantation (AST). Having gone from Council and Executive Board, he went on to become President of the Canadian Society of Transplantation from 2002-04. In the AST, he has served on the Board and many important committees including the co-chair of the Education Committee (2005-2007). He has organized many national and international meetings including the AST Fellows Meeting, American Transplant Congress (Chair 2009 - 2010), the AST 'Cutting Edge of Transplant (CEOT)' annual meeting and most recently the Ontario Transplant Forum (2015). He is the past Chair of the Advisory Board of the Canadian Institute of Health for Infection and Immunity (2009-2016) which covered transplantation and autoimmunity research in Canada.

Keywords:
Apoptosis
Apoptosis, Necrosis and cell death
Caspase regulation
Cytokines
Epithelial Cell
Immune biomarkers
Immunosuppression
Inflammation
Ischemia
Kidney
Kidney and tissue injury
Mouse models
Necroptosis
Organ preservation
Reperfusion
Transplant immunobiology
Transplantation


Nephrology
john.johnson@lhsc.on.ca
JOHN JOHNSON, BSc, MD, MSc, MHPE, FRCPC, Associate Professor

Associate Professor of Medicine, Division of Nephrology
Site Chief, Division of Nephrology, University Hospital
Program Director, Nephrology Transplant Fellowship
Associate Program Director, Nephrology Residency
Co-Chair, Epidemiology Course, Undergraduate Medical Education, Schulich School of Medicine and Dentistry, Western University
London Health Sciences Centre, London, Ontario, Canada
(Ph) 519-663-3319 (Fax) 519-663-3449

Keywords:
Peritoneal dialysis
Renal Transplantation


Nephrology
christopher.mcintyre@lhsc.on.ca
CHRIS MCINTYRE, MD, PhD, FRCPC, Professor

Dr. McIntyre is Professor of Medicine, Professor of Medical Biophysics, Professor of Paediatrics and Robert Lindsay Chair of Dialysis Research and Innovation at Western. He also serves as Director of the Lilibeth Caberto Kidney Clinical Research Unit at London Health Sciences Centre, where he is also a practicing Clinical Nephrologist. He leads a team of multidisciplinary researchers focused largely on the pathophysiology of the effecting cardiovascular, brain, liver and gastro-intestinal structure and function in patients with chronic kidney disease. These studies include basic clinical science, natural history studies and the development and application of novel therapeutic strategies into large scale randomized controlled trials. These studies have increasingly focused on the adverse consequences resulting from dialysis therapy itself and the improvement in outcomes by the reduction of preventable harm. Multimodal imaging plays an important role in these studies including ultrasound, CT, PET and MRI.

Keywords:
Applied Imaging
Cardio Renal Medicine
Chronic Kidney Disease
Hemodialysis
Peritoneal Dialysis


Nephrology
louise.moist@lhsc.on.ca
LOUISE MOIST, MD, FRCPC, MSc, Professor

Dr. Moist is a Clinician Researcher and Professor of Medicine and Epidemiology and Biostatistics at the University of Western Ontario and Associate Chair, Division of Nephrology at the London Health Sciences Centre. Dr. Moist is a Certified Canadian Physician Executive, credentialing her significant role in healthcare leadership. Dr. Moist is clinically active in both inpatient and outpatient settings and teaches students and residents at all levels of training including supervision of students completing a Masters in Epidemiology and Biostatistics.

Dr. Moist is Associate Director of the Center for Quality Innovation and Safety, Department of Medicine Western University. She is leading the first community antibiotic stewardship initiative for Ontario West and leads the discharge timeliness improvement project at LHSC. Dr. Moist is developing further knowledge in translation science and collaborative research.

Dr. Moist research interests include progression and treatment of chronic kidney disease (CKD), Obesity in CKD and vascular access, with a focus on implementation science. Dr. Moist has received peer-reviewed research funding from multiple sources including CIHR and Kidney Foundation of Canada, Her publications include over 250 peer reviewed papers

Dr. Moist has received a number of awards including e the Canadian Society of Nephrology Distinguished Service Award, MAC Chairs Award for outstanding contribution to quality improvement and patient safety Schulich School of Medicine & Dentistry Dean’s Award of Excellence in Undergraduate Education and an Award of Excellence in Research. Dr. Moist is recognized each year for her mentorship and leadership within the academic environment.

Keywords:
Chronic kidney disease
Diabetes Myelitis
Dialysis
Epidemiology
Health Care Outcomes
Health systems leadership
Hemodialysis
Knowledge translation
Obesity
Prevention
Quality Improvement
Vascular access


Nephrology
Pavel.Roshanov@lhsc.on.ca
PAVEL ROSHANOV, MD, FRCPC, Assistant Professor

Bio sketch unavailable at this time.


Nephrology
mweir@uwo.ca
MATTHEW WEIR, MD, FRCPC, MSc, Associate Professor

Dr. Weir is a nephrologist at the London Health Sciences Centre and the Medical Director of the Kidney Care Centre. He treats patients with chronic kidney disease including those who require dialysis or transplantation. His research interests relate to the interactions between pharmaceutics, impaired renal function and hemodialysis. Dr. Weir is honoured to be a part of the multidisciplinary team at the Kidney Clinical Research Unit where he seeks to generate new knowledge that will improve the health of patients suffering with kidney disease.

Keywords:
Renal Pharmacoepidemiology Drug Safety


Nephrology
zhuxu.zhang@lhsc.on.ca
ZHU-XU ZHANG, PHD, Associate Professor

Dr. Zhang graduated at Zhongshan University in China and late received his PhD degree from Karolinska Institute, Sweden in 1997. He finished his postdoctoral training in the Department of Pathology, University of Toronto in 2003. He is currently a professor in the Department of Medicine and the Department of Pathology at Western University. His laboratory is at the Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre. His research interest is focused on the mechanisms of immune regulation and tolerance. He and his colleagues have identified a novel type of regulatory T cells, double negative (DN-Treg) cells, that can suppress immune responses and prolong graft survival. In addition, his team has found that NK cells can mediate ischemia reperfusion injury and chronic rejection in transplantation. Recently, Dr. Zhang and colleagues were the first to describe the contribution of necroptosis in transplantation. Currently, there are two areas under active investigation in his laboratory: i) the mechanism of cell death pathways-mediated tissue injury and its effects on permitting tolerance induction in transplantation, and ii) the role of NK and T cells in immune tolerance. He is a member of AST, CST and AAI. His research has been supported by CIHR, CDTRP, HSF and KFOC.

Keywords:
Apoptosis
Kidney injury
Necroptosis
NK cell
Regulatory T cell
Transplantation