Program of Experimental Medicine - POEM
Department of Medicine

Program of Experimental Medicine
POEM


 Cardiology,  Cl Immunology and Allergy,  Clinical Pharmacology,  Critical Care Medicine, 
 Endocrinology and Metabolism, 
 Gastroenterology,  General Internal Medicine,  Geriatric Medicine, 
 Hematology, 
 Infectious Diseases, 
 Nephrology, 
 Respirology,  Rheumatology, 


Geriatric Medicine
Jaspreet.Bhangu@sjhc.london.on.ca
JASPREET BHANGU MD, FRCP(C), Assistant Professor

Dr. Jaspreet Bhangu joined the Division of Geriatric Medicine as Clinician Researcher in October 2019. He graduated from the Royal College of Surgeons in Ireland in 2004 and completed his PhD in Trinity College Dublin in 2016. He further completed a clinical fellowship in stroke neurology with the University of Toronto in 2017. His research interests include vascular causes of cognitive impairment, falls, orthostatic hypotension and syncope. He is a member of the Canadian Consortium on Neurodegeneration and Aging (CCNA) as well as the Cognitive Clinical Trials group within the division of Geriatric Medicine.

Keywords:
Cardiac disorders in older adults
Falls and syncope
Frailty
Orthostatic Hypotension and Autonomic Dysfunction


Geriatric Medicine
michael.borrie@sjhc.london.on.ca
MICHAEL BORRIE, MD, FRCPC, Professor

Dr. Michael Borrie is the Medical Director for the Aging Brain and Memory Clinic and is an investigator with the Cognitive Clinical Research Group. The group consists of investigators, clinical trials coordinators, clinicians and research assistants who do research in Neurodegenerative disorders. The group is based at Parkwood Institute and conducts investigator-initiated studies and pharmaceutical sponsored randomized controlled trials. As well, they provide education and clinical support to people with cognitive impairment and their families who are in the community. Dr. Borrie collaborates with Dr. Rob Bartha, Neuroimaging Scientist at the Robarts Research Institute, and his team of graduate students. These investigator-initiated neuroimaging studies have examined early markers of disease progression from Subjective Cognitive Decline to Mild Cognitive Impairment to Alzheimer Disease using magnetic resonance spectroscopy (MRS) and structural MRI at high magnetic field intensity. Dr. Borrie is the platform leader for the Canadian Collaboration on Neurodegeneration and Aging (CCNA), Compass-ND Study and is one of the 5 Canadian site investigators for the NIH funded North American Alzheimer Disease Neuroimaging Initiative (ADNI).

The Cognitive Clinical Research Group conducts pharmaceutical company sponsored randomized controlled trials of investigational compounds with the potential for disease modification in participants with underlying Alzheimer’s Disease. The trials are recruiting participants who are cognitively normal or have subjective cognitive decline or amnestic mild cognitive impairment or mild dementia. Underlying predisposition to Alzheimer’s Disease is confirmed with amyloid Positron Emission Tomography (PET) Imaging, CSF analysis and blood biomarkers.

Keywords:
Alzheimer's disease
Alzheimer's disease Disease Neuroimaging Initiative (ADNI)
Biomarkers
Canadian Collaboration on Neurodegeneration and Aging (CCNA)
Magnetic Resonance Imaging/Spectroscopy
Mild Cognitive Impairment
Neuroimaging studies
Randomized controlled trials


Geriatric Medicine
Monidipa.Dasgupta@sjhc.london.on.ca
MONIDIPA DASGUPTA, MD, FRCPC, Associate Professor

Dr. Dasgupta completed her medical degree from McGill University and did further post-graduate training in California (University of Southern California), University of Toronto and UWO. She completed her MSc. in epidemiology and biostatistics from UWO. She is actively involved in teaching residents and medical students in the medical clinical teaching units and the geriatric medicine subspecialty services. She is an active member of the Geriatric Fellowship Committee.

Keywords:
Acute care management of older adults
Delirium
Perioperative care of older adults


Geriatric Medicine
Manuel.MonteroOdasso@sjhc.london.on.ca
MANUEL MONTERO ODASSO, MD, PhD, FRCPC, AGSF, FGSA, Professor and Faculty Scholar

Manuel Montero-Odasso, MD (University of Buenos Aires, Argentina), PhD, (University of Buenos Aires, Argentina), Postdoctoral Fellowship (McGill University, Canada), is currently Professor in the Departments of Medicine, and Epidemiology and Biostatistics at Western, and Director of the “Gait and Brain Lab” at Parkwood Institute. He is an internist, geriatrician and clinician-scientist and serves as team leader at the Canadian Consortium on Neurodegeneration in Aging (CCNA) and at the Ontario Neurodegenerative Research Initiative (ONDRI).

He leads the Gait and Brain Health Program with the goal of understanding mechanisms and potential treatments of mobility and cognitive decline in older individuals. He focuses on gait performance and has established the use of “motor biomarkers” like slowing gait and dual-task gait to predict frailty, falls, and dementia. He has conducted clinical trials applying the novel approach of “improving cognition to improve mobility” using pharmacological and non-pharmacological treatments such as physical exercise, cognitive training and non-invasive brain stimulation. As team leader in CCNA (Canada Research Dementia Strategy) he is focusing in multi-domain clinical trials, including the SYNERGIC Trial, to delay dementia in older adults at risk (MCI spectrum) using physical exercises combined with cognitive training, dietary interventions (Vitamin D), sleep improvements and cardiometabolic factors control.

Dr. Montero-Odasso has created a successful research program while remaining an active clinician. His research has received uninterrupted peer-reviewed funding (>$9 M) from national and international agencies, including the Canadian Institutes of Health and Research (CIHR), Weston Brain Institute, and The Government of Ontario . He has published over two hundred peer-reviewed articles in high-impact journals in aging and neurosciences, including JAMA Neurol, Brain, Neurology, JGMS, and JAGS, and edited 2 books and sixteen chapters on aging, mild cognitive impairment and Alzheimer’s disease and mobility and falls . He has received several accolades including the American Geriatrics Society (AGS) New Investigator Award, the Schulich Clinician Scientist Award, the Premier of Ontario Excellence Research Award, the CIHR New Investigator Award, The CHS Kaufman Award. He was inducted as Honorary Member of the Spanish Geriatrics Society and Argentina Geriatrics Society, and selected as one of the Top 10 Most Influential Hispanic-Canadians. He serves as associate editor and board member of aging journals including, Journal of Alzheimer’s Disease, Geriatrics, and Journal of Gerontology Medical Sciences. He is member of the advisory board for the Institute of Aging (CIHR), CIHR review committee member, and vice president of the Canadian Geriatrics Society. He has delivered more than 100 international presentations as a guest or key-note speaker.

Keywords:
Alzheimer's disease
Balance
Clinical trials
Cognitive training
Dementia
Exercise
Frailty
Gait
Gait disorder
Geriatrics
Magnetic Resonance Imaging/Spectroscopy
Mild Cognitive Impairment
Mobility
Neuroimaging
Osteoporosis
Vitamin D