Program of Experimental Medicine - POEM
Department of Medicine

Program of Experimental Medicine
POEM


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Respirology
CONNIE MACKENZIE, MD, FRCPC, Associate Professor

Bio sketch unavailable at this time.

Keywords:
Clinical toxicology
Occupational lung disease
Pharmacogenetics of steroids in asthma


Endocrinology and Metabolism
JEFFREY MAHON, MD, MSc, FRCPC, FACP, Professor

Dr. Mahon graduated in medicine from the University of Alberta and trained in Internal Medicine and Endocrinology at Memorial University of Newfoundland and Western University. He received his Masters in Epidemiology and Biostatistics from Western and did a research fellowship in immunotherapy for type 1 diabetes at Western from 1988 - 1991. His research interests are in screening and preventing type 1 diabetes and N-of-1 trials.

Keywords:
N-of-1 trials
Screening and prevention
Type 1 diabetes


Hematology
JOY MANGEL, MD, FRCPC, Associate Professor

Dr. Joy Mangel is a clinical hematologist at the London Health Sciences Centre with a cross-appointment at the London Regional Cancer Program. She is an Associate Professor of Medicine at The Schulich School of Medicine, Western University. Dr. Mangel graduated from McGill Medical School in 1994, did her Internal Medicine and Hematology training at McGill University, and then did a 2 year research fellowship in the Advanced Therapeutic Program at the Toronto Sunnybrook Regional Cancer Centre specializing in clinical trials for lymphoma. She joined the Division of Hematology at Western University in 2003. Her main clinical and research interests include Hodgkin and non-Hodgkin lymphoma, and clinical trials for lymphoma. She is presently a local Principal Investigator for lymphoma and CLL clinical trials run through the Hematology Clinical Research Unit at London Regional Cancer Program. She sits on the Lymphoma Subcommittee for the National Cancer Institute of Canada Clinical Trials Group, and is a member of the Clinical Guidance Panel for the Pan-Canadian Oncology Drug Review (pCODR) Expert Review Committee. Dr. Mangel also has a special interest in medical education. She was the Program Director for the Western Postgraduate Training Program in Adult Hematology for 10 years. She is also passionate about physician wellness, and is presently the wellbeing lead for the Department of Medicine.

Keywords:
Hodgkin Lymphoma
Non-Hodgkin Lymphoma


Cardiology
JAIMIE MANLUCU, MD, FRCPC, Associate Professor

Dr. Manlucu is an Assistant Professor of Medicine at the University of Western Ontario and a member of the Arrhythmia Service at the London Health Sciences Centre (University Hospital) in London, Ontario.

She is a medical graduate of McMaster University and completed her Internal Medicine and General Cardiology training at Western University before going on to subspecialty training in Advanced Cardiac Electrophysiology at the Ottawa Heart Institute and Brigham and Women's Hospital (Harvard University, Boston, MA).

She joined the London Arrhythmia Service in 2012 where she is currently the Program Director of the Cardiac Electrophysiology Fellowship Training Program and the Director of Cardiac Implantable Device Program. She has a special interest in implantable cardiac devices, laser lead extraction and complex catheter ablation. Her research interests include cardiac resynchronization therapy, the management of atrial and ventricular arrhythmias, and the prevention of sudden death.

Keywords:
Arrhythmia
Cardiac Resynchronization Therapy (CRT)
Endocardial CRT
Sudden Cardiac Death


Respirology
DAVID MCCORMACK, MD, FRCPC, FCCP, Professor, Chair, Division of Respirology

David McCormack graduated from Queen’s University, Kingston, Ontario (1980) before completing fellowships in Respirology and Respiratory Research at Western University (1986) and National Heart and Lung Institute in London UK (1989). His current research interests include advanced lung imaging with MR and interventional bronchoscopy.

Dr. McCormack is a Professor of Medicine and Chair of the Division of Respirology at Western University.

Keywords:
Interventional bronchoscopy
Lung MR imaging


Nephrology
CHRIS MCINTYRE, MD, PhD, FRCPC, Professor

Dr. McIntyre is Professor of Medicine, Professor of Medical Biophysics, Professor of Paediatrics and Robert Lindsay Chair of Dialysis Research and Innovation at Western. He also serves as Director of the Lilibeth Caberto Kidney Clinical Research Unit at London Health Sciences Centre, where he is also a practicing Clinical Nephrologist. He leads a team of multidisciplinary researchers focused largely on the pathophysiology of the effecting cardiovascular, brain, liver and gastro-intestinal structure and function in patients with chronic kidney disease. These studies include basic clinical science, natural history studies and the development and application of novel therapeutic strategies into large scale randomized controlled trials. These studies have increasingly focused on the adverse consequences resulting from dialysis therapy itself and the improvement in outcomes by the reduction of preventable harm. Multimodal imaging plays an important role in these studies including ultrasound, CT, PET and MRI.

Keywords:
Applied Imaging
Cardio Renal Medicine
Chronic Kidney Disease
Hemodialysis
Peritoneal Dialysis


Endocrinology and Metabolism
RUTH MCMANUS, MD, FRCPC, Professor

Dr McManus graduated from UWO in Internal Medicine in 1985. She took additional training in Endocrinology at Dalhousie in Halifax and the University of Alberta in Edmonton, attaining certification in Endocrinology and Metabolism in 1992. Since 1992 she has been consultant in the Division of Endocrinology and Metabolism at UWO, promoted to full professor in 2010. Her research interests are: insulin resistance states, Vitamin D effects in metabolic disease, gestational diabetes and primary prevention of diabetes.

Keywords:
Diabetes prevention
Gestational Diabetes (GMD)
Insulin resistance


Respirology
SANJAY MEHTA, MD, FRCP(C)

Sanjay Mehta grew up in Montreal, and graduated from McGill University in Montreal in 1988. He completed residency in Internal Medicine and a Fellowships in Pulmonary Medicine at McGill. He began his research training at McGill, before completing Fellowships in Pulmonary Research at Harvard University, Boston and Victoria Hospital, London.

Current positions include:
• Professor of Medicine, Schulich School of Medicine & Dentistry, Western University
• Consultant Respirologist and Director of the Southwest Ontario Pulmonary Hypertension Clinic, London Health Sciences Center
• Clinician-Scientist, Program of Critical Illness Research, Lawson Health Research Institute, LHSC
• Founding Board Member 2008 / Chair of the Board of Directors 2013-2019 / Eternal PHriend of PHA Canada 2018, Pulmonary Hypertension Association (PHA) of Canada


Dr Mehta has been looking after PH patients for 30 years, since he was a resident at McGill in the 1980s, and as a PH specialist in London since 1996. He has also participated in many clinical research studies with PH patients. He is very active in the education of physicians and healthcare providers about PH, and has been part of many Canadian and international PH guidelines.

Keywords:
Acute lung injury
Endothelial cell biology
Exercise physiology
Nitric oxide biology
Pulmonary hypertension
Respiratory physiology
Sepsis


Nephrology
LOUISE MOIST, MD, FRCPC, MSc, Professor

Dr. Moist is a Clinician Researcher and Professor of Medicine and Epidemiology and Biostatistics at the University of Western Ontario and Associate Chair, Division of Nephrology at the London Health Sciences Centre. Dr. Moist is a Certified Canadian Physician Executive, credentialing her significant role in healthcare leadership. Dr. Moist is clinically active in both inpatient and outpatient settings and teaches students and residents at all levels of training including supervision of students completing a Masters in Epidemiology and Biostatistics.

Dr. Moist is Associate Director of the Center for Quality Innovation and Safety, Department of Medicine Western University. She is leading the first community antibiotic stewardship initiative for Ontario West and leads the discharge timeliness improvement project at LHSC. Dr. Moist is developing further knowledge in translation science and collaborative research.

Dr. Moist research interests include progression and treatment of chronic kidney disease (CKD), Obesity in CKD and vascular access, with a focus on implementation science. Dr. Moist has received peer-reviewed research funding from multiple sources including CIHR and Kidney Foundation of Canada, Her publications include over 250 peer reviewed papers

Dr. Moist has received a number of awards including e the Canadian Society of Nephrology Distinguished Service Award, MAC Chairs Award for outstanding contribution to quality improvement and patient safety Schulich School of Medicine & Dentistry Dean’s Award of Excellence in Undergraduate Education and an Award of Excellence in Research. Dr. Moist is recognized each year for her mentorship and leadership within the academic environment.

Keywords:
Chronic kidney disease
Diabetes Myelitis
Dialysis
Epidemiology
Health Care Outcomes
Health systems leadership
Hemodialysis
Knowledge translation
Obesity
Prevention
Quality Improvement
Vascular access


Geriatric Medicine
MANUEL MONTERO ODASSO, MD, PhD, FRCPC, AGSF, FGSA, Professor and Faculty Scholar

Manuel Montero-Odasso, MD (University of Buenos Aires, Argentina), PhD, (University of Buenos Aires, Argentina), Postdoctoral Fellowship (McGill University, Canada), is currently Professor in the Departments of Medicine, and Epidemiology and Biostatistics at Western, and Director of the “Gait and Brain Lab” at Parkwood Institute. He is an internist, geriatrician and clinician-scientist and serves as team leader at the Canadian Consortium on Neurodegeneration in Aging (CCNA) and at the Ontario Neurodegenerative Research Initiative (ONDRI).

He leads the Gait and Brain Health Program with the goal of understanding mechanisms and potential treatments of mobility and cognitive decline in older individuals. He focuses on gait performance and has established the use of “motor biomarkers” like slowing gait and dual-task gait to predict frailty, falls, and dementia. He has conducted clinical trials applying the novel approach of “improving cognition to improve mobility” using pharmacological and non-pharmacological treatments such as physical exercise, cognitive training and non-invasive brain stimulation. As team leader in CCNA (Canada Research Dementia Strategy) he is focusing in multi-domain clinical trials, including the SYNERGIC Trial, to delay dementia in older adults at risk (MCI spectrum) using physical exercises combined with cognitive training, dietary interventions (Vitamin D), sleep improvements and cardiometabolic factors control.

Dr. Montero-Odasso has created a successful research program while remaining an active clinician. His research has received uninterrupted peer-reviewed funding (>$9 M) from national and international agencies, including the Canadian Institutes of Health and Research (CIHR), Weston Brain Institute, and The Government of Ontario . He has published over two hundred peer-reviewed articles in high-impact journals in aging and neurosciences, including JAMA Neurol, Brain, Neurology, JGMS, and JAGS, and edited 2 books and sixteen chapters on aging, mild cognitive impairment and Alzheimer’s disease and mobility and falls . He has received several accolades including the American Geriatrics Society (AGS) New Investigator Award, the Schulich Clinician Scientist Award, the Premier of Ontario Excellence Research Award, the CIHR New Investigator Award, The CHS Kaufman Award. He was inducted as Honorary Member of the Spanish Geriatrics Society and Argentina Geriatrics Society, and selected as one of the Top 10 Most Influential Hispanic-Canadians. He serves as associate editor and board member of aging journals including, Journal of Alzheimer’s Disease, Geriatrics, and Journal of Gerontology Medical Sciences. He is member of the advisory board for the Institute of Aging (CIHR), CIHR review committee member, and vice president of the Canadian Geriatrics Society. He has delivered more than 100 international presentations as a guest or key-note speaker.

Keywords:
Alzheimer's disease
Balance
Clinical trials
Cognitive training
Dementia
Exercise
Frailty
Gait
Gait disorder
Geriatrics
Magnetic Resonance Imaging/Spectroscopy
Mild Cognitive Impairment
Mobility
Neuroimaging
Osteoporosis
Vitamin D


General Internal Medicine
MARKO MRKOBRADA, MD, FRCPC, Hon BSc, Associate Professor

I joined the Division of General Internal Medicine as an Assistant Professor in July 2009, and I’m currently pursuing a graduate degree in Clinical Epidemiology from McMaster University under the supervision of Dr. P.J. Devereaux.

I am the principal investigator for an ongoing 200-person RCT of ACEi/ARB management before surgery, and a 70-person observational study of covert stroke and delirium after surgery. I am also the project officer for POISE-2, a 10,000-person factorial RCT of ASA and clonidine in surgical patients, and the site PI for CTA-VISION, an observational study assessing the utility of CT angiograms before noncardiac surgery.

My academic interests focus on:

• Perioperative medicine. Every year, approximately three million patients in Canada undergo elective surgery, but it carries a significant risk of cardiovascular morbidity and mortality. Unfortunately, there is a paucity of evidence regarding the optimal medical management of patients during this time period. I am currently working on multiple observational and interventional studies in this population.

• Acute inpatient medicine. This is a very diverse population, with a great deal of morbidity and a high risk of mortality, and few studies exist in this area. I am interested in characterizing the epidemiology of this population, and working on system-based improvements in the delivery of health care for these patients.

• Cognitive dysfunction in hospitalized patients. Cognitive dysfunction is a spectrum that ranges from mild memory impairment to severe delirium. There is a high incidence of cognitive dysfunction after surgery, and during hospitalization for a medical illness. I am interested in looking at the pathophysiology and epidemiology of cognitive dysfunction, as well as interventions focused on prophylaxis and treatment of cognitive dysfunction.

Keywords:
Cardiovascular disease
Clinical Epidemiology
Cognitive Dysfunction
Delirium
Inpatient medicine
Inpatient medicine, Acute
Medical imaging
Meta-analysis
Observational studies
Perioperative medicine
Randomized controlled trials
Stroke and cerebrovascular disease
Systematic reviews


Respirology
MARCO MURA, MD, PHD, Associate Professor

Dr. Marco Mura, MD, PhD, is a Clinician Researcher in the Division of Respirology at Western University.

Dr. Mura graduated from the University of Bologna (Italy) in 2001 and obtained his PhD in 2005 from the same University upon completing a research fellowship on acute lung injury at the Latner Thoracic Surgery Research Laboratories, University of Toronto. He completed his Respiratory Medicine training at the University of Rome Tor Vergata in 2008 and returned to Canada to undergo additional clinical training and conduct translational research projects in lung transplantation, pulmonary hypertension and interstitial lung disease (ILD).

Interstitial lung disease and pulmonary hypertension are therefore his main clinical and research interests. After joining Western University in 2012, he established an ILD clinic in London and joined the Pulmonary Hypertension Program as Co-Director. He is Associate Scientist at the Lawson Research Institute.

His current research projects include the development of staging systems for idiopathic pulmonary fibrosis, translational research in ILD to identify novel biomarkers and therapeutic targets for UIP and NSIP, and new clinical trials for IPF.

Keywords:
Interstitial lung disease
Pulmonary fibrosis
Pulmonary hypertension