Program of Experimental Medicine - POEM
Department of Medicine

Program of Experimental Medicine
POEM


 A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z 


Respirology
CONNIE MACKENZIE, MD, FRCPC, Associate Professor

Bio sketch unavailable at this time.

Keywords:
Clinical toxicology
Occupational lung disease
Pharmacogenetics of steroids in asthma


Hematology
JOY MANGEL, MD, FRCPC, Associate Professor

Dr. Joy Mangel is a clinical hematologist at the London Health Sciences Centre with a cross-appointment at the London Regional Cancer Program. She is an Associate Professor of Medicine at The Schulich School of Medicine, Western University. Dr. Mangel graduated from McGill Medical School in 1994, did her Internal Medicine and Hematology training at McGill University, and then did a 2-year research fellowship in the Advanced Therapeutic Program at the Toronto Sunnybrook Regional Cancer Centre specializing in clinical trials for lymphoma. She joined the Division of Hematology at Western University in 2003. Her main clinical and research interests include Hodgkin and non-Hodgkin lymphoma, CLL, and clinical trials. Dr. Mangel also has special interests in medical education and physician wellbeing, and is presently the wellbeing lead for the Department of Medicine and the LHSC Credentialed Professional Staff Wellbeing Lead.

Keywords:
Hodgkin Lymphoma
Non-Hodgkin Lymphoma
Physician Wellbeing 


Cardiology
JAIMIE MANLUCU, MD, FRCPC, Associate Professor

Dr. Manlucu is an Assistant Professor of Medicine at the University of Western Ontario and a member of the Arrhythmia Service at the London Health Sciences Centre (University Hospital) in London, Ontario.

She is a medical graduate of McMaster University and completed her Internal Medicine and General Cardiology training at Western University before going on to subspecialty training in Advanced Cardiac Electrophysiology at the Ottawa Heart Institute and Brigham and Women's Hospital (Harvard University, Boston, MA).

She joined the London Arrhythmia Service in 2012 where she is currently the Program Director of the Cardiac Electrophysiology Fellowship Training Program and the Director of Cardiac Implantable Device Program. She has a special interest in implantable cardiac devices, laser lead extraction and complex catheter ablation. Her research interests include cardiac resynchronization therapy, the management of atrial and ventricular arrhythmias, and the prevention of sudden death.

Keywords:
Arrhythmia
Cardiac Resynchronization Therapy (CRT)
Endocardial CRT
Sudden Cardiac Death


Nephrology
CHRIS MCINTYRE, MD, PhD, FRCPC, Professor

Dr. McIntyre is Professor of Medicine, Professor of Medical Biophysics, Professor of Paediatrics and Robert Lindsay Chair of Dialysis Research and Innovation at Western. He also serves as Director of the Lilibeth Caberto Kidney Clinical Research Unit at London Health Sciences Centre, where he is also a practicing Clinical Nephrologist. He leads a team of multidisciplinary researchers focused largely on the pathophysiology of the effecting cardiovascular, brain, liver and gastro-intestinal structure and function in patients with chronic kidney disease. These studies include basic clinical science, natural history studies and the development and application of novel therapeutic strategies into large scale randomized controlled trials. These studies have increasingly focused on the adverse consequences resulting from dialysis therapy itself and the improvement in outcomes by the reduction of preventable harm. Multimodal imaging plays an important role in these studies including ultrasound, CT, PET and MRI.

Keywords:
Applied Imaging
Cardio Renal Medicine
Chronic Kidney Disease
Hemodialysis
Peritoneal Dialysis


Respirology
SANJAY MEHTA, MD, FRCP(C)

Sanjay Mehta grew up in Montreal, and graduated from McGill University in Montreal in 1988. He completed residency in Internal Medicine and a Fellowships in Pulmonary Medicine at McGill. He began his research training at McGill, before completing Fellowships in Pulmonary Research at Harvard University, Boston and Victoria Hospital, London.

Current positions include:
• Professor of Medicine, Schulich School of Medicine & Dentistry, Western University
• Consultant Respirologist and Director of the Southwest Ontario Pulmonary Hypertension Clinic, London Health Sciences Center
• Clinician-Scientist, Program of Critical Illness Research, Lawson Health Research Institute, LHSC
• Founding Board Member 2008 / Chair of the Board of Directors 2013-2019 / Eternal PHriend of PHA Canada 2018, Pulmonary Hypertension Association (PHA) of Canada


Dr Mehta has been looking after PH patients for 30 years, since he was a resident at McGill in the 1980s, and as a PH specialist in London since 1996. He has also participated in many clinical research studies with PH patients. He is very active in the education of physicians and healthcare providers about PH, and has been part of many Canadian and international PH guidelines.

Keywords:
Acute lung injury
Endothelial cell biology
Exercise physiology
Nitric oxide biology
Pulmonary hypertension
Respiratory physiology
Sepsis


Nephrology
LOUISE MOIST, MD, FRCPC, MSc, Professor

Dr. Moist is a Clinician Scientist and Professor of Medicine and Epidemiology and Biostatistics at the University of Western Ontario and the William F. Clark Chair, Division of Nephrology at the London Health Sciences Centre. Dr. Moist is a Certified Canadian Physician Executive, credentialing her significant role in healthcare leadership. Dr. Moist is clinically active in both inpatient and outpatient settings and teaches students and residents at all levels of training including supervision of students completing a Masters in Epidemiology and Biostatistics.

Dr. Moist’s research interests include progression and treatment of chronic kidney disease (CKD), obesity in CKD and vascular access, with a focus on implementation science. Dr. Moist has received peer-reviewed research funding from multiple sources including CIHR and Kidney Foundation of Canada, Her publications include over 250 peer reviewed papers

Dr. Moist has received a number of awards including e the Canadian Society of Nephrology Distinguished Service Award, MAC Chairs Award for outstanding contribution to quality improvement and patient safety Schulich School of Medicine & Dentistry Dean’s Award of Excellence in Undergraduate Education and an Award of Excellence in Research. Dr. Moist is recognized each year for her mentorship and leadership within the academic environment.

Keywords:
Chronic kidney disease
Diabetes Myelitis
Dialysis
Epidemiology
Health Care Outcomes
Health systems leadership
Hemodialysis
Knowledge translation
Obesity
Prevention
Quality Improvement
Vascular access


Geriatric Medicine
MANUEL MONTERO ODASSO, MD, PhD, FRCPC, AGSF, FGSA, FCAHS, Professor

Manuel Montero-Odasso, MD (University of Buenos Aires, Argentina), PhD, (University of Buenos Aires, Argentina), Postdoctoral Fellowship (McGill University, Canada), is currently a Professor in the Departments of Medicine, and Epidemiology and Biostatistics at Western University, and Director of the Gait and Brain Lab at Parkwood Institute. He is an internist, geriatrician, and clinician-scientist, and serves as team leader at the Canadian Consortium on Neurodegeneration in Aging (CCNA) and Director of the Brain Health Care Training Platform (BHCare). He also holds the inaugural Wolfe Research Professorship in Aging.

Dr. Montero-Odasso leads the Gait and Brain Health Program, which aims to understand the mechanisms and potential treatments for mobility and cognitive decline in ageing. His research focuses on gait performance, and he has established the use of “motor biomarkers” such as gait slowing and dual-task gait to predict frailty, falls, and dementia. He has conducted clinical trials applying the novel approach of “improving cognition to improve mobility” using both pharmacological and non-pharmacological treatments, including physical exercise, cognitive training, and non-invasive brain stimulation. As team leader in CCNA (Canada Research Dementia Strategy), he focuses on multi-domain clinical trials, including the SYNERGIC Trials, which aim to delay dementia in older adults at risk (MCI spectrum) through interventions like physical exercise, cognitive training, dietary interventions (Vitamin D), sleep improvements, and control of cardiometabolic factors.

He has built a successful research program while maintaining an active clinical practice. His research has received continuous peer-reviewed funding (> $16M) from national and international agencies, including the Canadian Institutes of Health and Research, Weston Brain Institute, and The Government of Ontario. He has published over three hundred peer-reviewed articles in high-impact journals in aging and neuroscience, including JAMA, JAMA Neurology and Open, Brain, Neurology, JGMS, and JAGS. Additionally, he has edited two books and eighteen chapters on topics related to aging, mild cognitive impairment, Alzheimer’s disease, and mobility and falls.

Dr. Montero-Odasso has received numerous national and international accolades, including the American Geriatrics Society New Investigator Award, the Premier of Ontario Excellence Research Award, the Schulich Clinician Scientist Award, the CIHR Investigator Award, and recognition as one of the top ten Hispanic-Canadians for his contribution to Medicine and Science. He has delivered over 100 keynote addresses. His research impact is further demonstrated by his ranking in the prestigious Stanford University Report as one of the ‘Top 2% world scientists’. In 2024, he was inducted as a Fellow in the Canadian Academy of Health Sciences, one of the highest honours in Canadian Medicine.

Keywords:
Alzheimer's disease
Balance
Clinical trials
Cognitive training
Dementia
Exercise
Frailty
Gait
Gait disorder
Geriatrics
Magnetic Resonance Imaging/Spectroscopy
Mild Cognitive Impairment
Mobility
Neuroimaging
Osteoporosis
Vitamin D


General Internal Medicine
MARKO MRKOBRADA, MD, FRCPC, Hon BSc, Associate Professor

I joined the Division of General Internal Medicine as an Assistant Professor in July 2009, and I’m currently pursuing a graduate degree in Clinical Epidemiology from McMaster University under the supervision of Dr. P.J. Devereaux.

I am the principal investigator for an ongoing 200-person RCT of ACEi/ARB management before surgery, and a 70-person observational study of covert stroke and delirium after surgery. I am also the project officer for POISE-2, a 10,000-person factorial RCT of ASA and clonidine in surgical patients, and the site PI for CTA-VISION, an observational study assessing the utility of CT angiograms before noncardiac surgery.

My academic interests focus on:

• Perioperative medicine. Every year, approximately three million patients in Canada undergo elective surgery, but it carries a significant risk of cardiovascular morbidity and mortality. Unfortunately, there is a paucity of evidence regarding the optimal medical management of patients during this time period. I am currently working on multiple observational and interventional studies in this population.

• Acute inpatient medicine. This is a very diverse population, with a great deal of morbidity and a high risk of mortality, and few studies exist in this area. I am interested in characterizing the epidemiology of this population, and working on system-based improvements in the delivery of health care for these patients.

• Cognitive dysfunction in hospitalized patients. Cognitive dysfunction is a spectrum that ranges from mild memory impairment to severe delirium. There is a high incidence of cognitive dysfunction after surgery, and during hospitalization for a medical illness. I am interested in looking at the pathophysiology and epidemiology of cognitive dysfunction, as well as interventions focused on prophylaxis and treatment of cognitive dysfunction.

Keywords:
Cardiovascular disease
Clinical Epidemiology
Cognitive Dysfunction
Delirium
Inpatient medicine
Inpatient medicine, Acute
Medical imaging
Meta-analysis
Observational studies
Perioperative medicine
Randomized controlled trials
Stroke and cerebrovascular disease
Systematic reviews