Program of Experimental Medicine - POEM
Department of Medicine

Program of Experimental Medicine
POEM


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General Internal Medicine
SAIRA ZAFAR, MD, FRCPC, Associate Professor

Dr. Saira Zafar is an Associate Professor in Department of Medicine at Western University. She completed her medical school from King Edward Medical University, Pakistan. She did her core internal medicine residency and fellowship in General Internal Medicine from Western University. During her core residency, she developed interest in Quality improvement and Patient safety after winning excellence in research award for her work on medical errors in the clinical teaching units. She went on to do a clinical scholar year at Western with focus on improving inpatient medical unit’s quality of care. She is involved with various quality improvement projects such as improving hand hygiene compliance rates of residents and medical students and medication reconciliation. She is also working on implementing strategies to identify high risk patients for readmission in order to provide intensive peri-discharge care to reduce readmission rates. She is also involved with QI curriculum for GIM postgraduate trainees and supervises their QI research projects.

Keywords:
Patient Safety
Prevention of Readmissions to Hospitals
Quality Improvement


Nephrology
ZHU-XU ZHANG, PHD, Associate Professor

Dr. Zhang graduated at Zhongshan University in China and late received his PhD degree from Karolinska Institute, Sweden in 1997. He finished his postdoctoral training in the Department of Pathology, University of Toronto in 2003. He is currently a professor in the Department of Medicine and the Department of Pathology at Western University. His laboratory is at the Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre. His research interest is focused on the mechanisms of immune regulation and tolerance. He and his colleagues have identified a novel type of regulatory T cells, double negative (DN-Treg) cells, that can suppress immune responses and prolong graft survival. In addition, his team has found that NK cells can mediate ischemia reperfusion injury and chronic rejection in transplantation. Recently, Dr. Zhang and colleagues were the first to describe the contribution of necroptosis in transplantation. Currently, there are two areas under active investigation in his laboratory: i) the mechanism of cell death pathways-mediated tissue injury and its effects on permitting tolerance induction in transplantation, and ii) the role of NK and T cells in immune tolerance. He is a member of AST, CST and AAI. His research has been supported by CIHR, CDTRP, HSF and KFOC.

Keywords:
Apoptosis
Kidney injury
Necroptosis
NK cell
Regulatory T cell
Transplantation